MolNFT v1 · #157555 · protein
Sega-long, conformation of tdp-43 low complexity domain segment a long
6N3A · Tar DNA-binding protein 43: “Sega-long, conformation of tdp-43 low complexity domain segment a long”. Electron microscopy, 2 pockets (best druggability 0.37). MolNFT v1 #157555 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6N3A
- Type
- protein
- Length
- 600 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar DNA-binding protein 43; Sega long small
- UniProt
- Q13148
- Pockets
- 2 · best druggability 0.37
Structure
electron microscopy · 2 distinct chains · 0% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Tar DNA-binding protein 43 | protein | 50 | 0% helix, 62% strand | Q13148 |
| K, L, M, N, O, P, Q, R, S, T | Sega long small | protein | 10 | 0% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.37 | 0.75 | 21 | empty |
| 2 | 80 | 0.37 | 0.77 | 19 | empty |
Interfaces
59 interfaces between chains.
- A–F · 1968 Ų buried · 74 hydrogen bonds · protein-protein
- F–I · 1966 Ų buried · 74 hydrogen bonds · protein-protein
- B–E · 1964 Ų buried · 74 hydrogen bonds · protein-protein
- C–H · 1964 Ų buried · 74 hydrogen bonds · protein-protein
- D–G · 1963 Ų buried · 73 hydrogen bonds · protein-protein
Compared structures
- 6N3A · SegA-long, conformation of TDP-43 low complexity domain segment A long · the same entry in another collection · chain T against T, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13148
- Elsewhere: RCSB PDB 6N3A · PDBe 6N3A · UniProt Q13148
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