MolNFT v1 · #157518 · protein

BEST1 open state W287F mutant, calcium-free

6N24 · Bestrophin homolog: “BEST1 open state W287F mutant, calcium-free”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #157518 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N24
Type: protein
Length: 1,530 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bestrophin homolog
UniProt: E1C3A0
Pockets: 20 · best druggability 0.77

Structure

electron microscopy · 1 distinct chain · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Bestrophin homolog	protein	306	65% helix, 0% strand	E1C3A0

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	904	0.77	0.79	91	empty
2	390	0.73	0.84	49	empty
3	359	0.71	0.83	44	empty
4	658	0.69	0.78	38	empty
5	165	0.65	0.86	25	empty

Interfaces

5 interfaces between chains.

D–E · 3500 Å² buried · 24 hydrogen bonds · protein-protein
C–D · 3492 Å² buried · 25 hydrogen bonds · protein-protein
B–C · 3484 Å² buried · 24 hydrogen bonds · protein-protein
A–E · 3482 Å² buried · 24 hydrogen bonds · protein-protein
A–B · 3470 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6N24 · BEST1 open state W287F mutant, calcium-free · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E1C3A0
Elsewhere: RCSB PDB 6N24 · PDBe 6N24 · UniProt E1C3A0

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