MolNFT v1 · #157513 · protein

Importin-9 bound to H2A-H2B

6N1Z: “Importin-9 bound to H2A-H2B”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #157513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N1Z
Type: protein
Length: 2,270 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin-9; Histone H2A; Histone H2B 1.1
UniProt: Q96P70, Q6AZJ8, P02281
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 6 distinct chains · 73% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin-9	protein	961	73% helix, 1% strand	Q96P70
B	Histone H2A	protein	86	69% helix, 3% strand	Q6AZJ8
C	Histone H2B 1.1	protein	92	73% helix, 3% strand	P02281
D	Importin-9	protein	949	74% helix, 1% strand	Q96P70
E	Histone H2A	protein	85	69% helix, 4% strand	Q6AZJ8
F	Histone H2B 1.1	protein	97	66% helix, 3% strand	P02281

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	995	0.79	0.81	99	empty
2	602	0.78	0.84	53	empty
3	932	0.75	0.78	74	empty
4	569	0.73	0.81	48	empty
5	519	0.69	0.79	67	empty

Interfaces

7 interfaces between chains.

E–F · 2643 Å² buried · 27 hydrogen bonds · protein-protein
B–C · 2580 Å² buried · 24 hydrogen bonds · protein-protein
D–F · 2329 Å² buried · 35 hydrogen bonds · protein-protein
A–C · 2050 Å² buried · 24 hydrogen bonds · protein-protein
D–E · 1004 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

6N1Z · Importin-9 bound to H2A-H2B · the same entry in another collection · chain F against F, TM-score 1.00
Q96P70 · AlphaFold monomer V2.0 prediction for importin-9 (Q96P70) · a predicted model of the same protein · chain D against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96P70
Every structure of UniProt Q6AZJ8
Every structure of UniProt P02281
Elsewhere: RCSB PDB 6N1Z · PDBe 6N1Z · UniProt Q96P70 · UniProt Q6AZJ8 · UniProt P02281

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