MolNFT v1 · #157455 · protein
Tas-120 in reversible binding mode with FGFR1
6MZQ · Fibroblast growth factor receptor 1: “Tas-120 in reversible binding mode with FGFR1”. X-ray diffraction, 1 ligand (TZ0), 4 pockets (best druggability 0.63). MolNFT v1 #157455 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6MZQ
- Type
- protein
- Length
- 537 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P11362
- Ligands
- TZ0
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 277 | 39% helix, 16% strand | P11362 |
| B | Fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 260 | 42% helix, 17% strand | P11362 |
Ligands and binding sites
- TZ0 · 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 518 | 0.63 | 0.76 | 66 | empty |
| 2 | 232 | 0.60 | 0.80 | 30 | TZ0 |
| 3 | 224 | 0.58 | 0.79 | 29 | TZ0 |
| 4 | 62 | 0.34 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 390 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 6MZQ · PDBe 6MZQ · UniProt P11362
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