MolNFT v1 · #157405 · protein

Structure of 53BP1 tandem tudor domains with E1549P and D1550N mutations

6MY0 · TP53-binding protein 1: “Structure of 53BP1 tandem tudor domains with E1549P and D1550N mutations”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #157405 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6MY0
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TP53-binding protein 1
UniProt: Q12888
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TP53-binding protein 1	protein	122	14% helix, 52% strand	Q12888
B	TP53-binding protein 1	protein	118	13% helix, 56% strand	Q12888

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.55	0.80	30	empty

Interfaces

1 interface between chains.

A–B · 487 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6MY0 · Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12888
Elsewhere: RCSB PDB 6MY0 · PDBe 6MY0 · UniProt Q12888

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