MolNFT v1 · #157314 · protein
2.05A resolution structure of the cs-B5R domains of human NCB5OR (NADP+ form)
6MV2 · Cytochrome B5 reductase 4: “2.05A resolution structure of the cs-B5R domains of human NCB5OR (NADP+ form)”. X-ray diffraction, 2 ligands (FAD, NAP), 3 pockets (best druggability 0.73). MolNFT v1 #157314 on GenesisL1: 3D structure…
- PDB
- 6MV2
- Type
- protein
- Length
- 356 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome B5 reductase 4
- EC
- 1.6.2.2
- UniProt
- Q7L1T6
- Ligands
- FAD, NAP
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome B5 reductase 4 (EC 1.6.2.2) | protein | 356 | 18% helix, 39% strand | Q7L1T6 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 663 | 0.73 | 0.79 | 66 | empty |
| 2 | 357 | 0.61 | 0.77 | 42 | FAD, NAP |
| 3 | 72 | 0.31 | 0.74 | 15 | empty |
Compared structures
- 6MV2 · 2.05A resolution structure of the CS-b5R domains of human Ncb5or (NADP+ form) · the same entry in another collection · chain A against A, TM-score 1.00
- Q7L1T6 · AlphaFold monomer V2.0 prediction for cytochrome B5 reductase 4 (Q7L1T6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7L1T6
- Elsewhere: RCSB PDB 6MV2 · PDBe 6MV2 · UniProt Q7L1T6
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