MolNFT v1 · #157232 · protein
Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (cftr)
6MSM: “Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (cftr)”. Electron microscopy, 4 ligands (POV, ATP, CLR). MolNFT v1 #157232 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MSM
- Type
- protein
- Length
- 1,198 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P13569
- Ligands
- POV, ATP, CLR, MG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1181 | — | P13569 |
| B | — | protein | 17 | — | — |
Ligands and binding sites
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 5 copies · chains A
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- CLR · Cholesterol · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6MSM · Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) · the same entry in another collection · chain B against B, TM-score 1.00
- P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13569
- Elsewhere: RCSB PDB 6MSM · PDBe 6MSM · UniProt P13569
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