MolNFT v1 · #157171 · protein

Crystal structure of GTPase domain of human septin 12 mutant T89M

6MQL · Septin-12: “Crystal structure of GTPase domain of human septin 12 mutant T89M”. X-ray diffraction, 2 ligands (GDP, MG), 1 pocket (best druggability 0.40). MolNFT v1 #157171 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6MQL
Type: protein
Length: 263 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Septin-12
UniProt: Q8IYM1
Ligands: GDP, MG
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Septin-12	protein	263	40% helix, 19% strand	Q8IYM1

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.40	0.76	14	empty

Compared structures

6MQL · Crystal Structure of GTPase Domain of Human Septin 12 Mutant T89M · the same entry in another collection · chain A against A, TM-score 1.00
Q8IYM1 · AlphaFold monomer V2.0 prediction for septin-12 (Q8IYM1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYM1
Elsewhere: RCSB PDB 6MQL · PDBe 6MQL · UniProt Q8IYM1

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