MolNFT v1 · #157005 · protein
Crystal structure of the periplasmic lysine-, arginine-, ornithine- binding protein (lao) S70A mutant from salmonella typhimurium complexed with arginine
6MLJ · LYSINE/ARGININE/ORNITHINE transport protein: “Crystal structure of the periplasmic lysine-, arginine-, ornithine- binding protein (lao) S70A mutant from…”. X-ray diffraction, 1 ligand (ARG), 4 pockets (best druggability 0.49).…
- PDB
- 6MLJ
- Type
- protein
- Length
- 474 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LYSINE/ARGININE/ORNITHINE transport protein
- UniProt
- A0A0F6B499
- Ligands
- ARG
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | LYSINE/ARGININE/ORNITHINE transport protein | protein | 237 | 38% helix, 22% strand | A0A0F6B499 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.49 | 0.77 | 33 | empty |
| 2 | 205 | 0.48 | 0.75 | 38 | empty |
| 3 | 77 | 0.39 | 0.78 | 19 | empty |
| 4 | 73 | 0.38 | 0.77 | 18 | ACT |
Interfaces
1 interface between chains.
- A–B · 247 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6MLJ · Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0F6B499
- Elsewhere: RCSB PDB 6MLJ · PDBe 6MLJ · UniProt A0A0F6B499
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