MolNFT v1 · #15694 · protein

The receptor-binding domain of human B7-2

1NCN · T lymphocyte activation antigen CD86: “The receptor-binding domain of human B7-2”. X-ray diffraction, 2 pockets (best druggability 0.39). MolNFT v1 #15694 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NCN
Type: protein
Length: 220 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T lymphocyte activation antigen CD86
UniProt: P42081
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	T lymphocyte activation antigen CD86	protein	110	5% helix, 53% strand	P42081

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.39	0.75	30	empty
2	76	0.30	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 463 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1NCN · the receptor-binding domain of human B7-2 · the same entry in another collection · chain A against A, TM-score 1.00
P42081 · AlphaFold monomer V2.0 prediction for T-lymphocyte activation antigen CD86 (P42081) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42081
Elsewhere: RCSB PDB 1NCN · PDBe 1NCN · UniProt P42081

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