MolNFT v1 · #156801 · protein
Mouse TALIN1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2)
6MFS · Talin-1 fusion: “Mouse TALIN1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate…”. X-ray diffraction, 2 ligands (PIO, PO4), 3 pockets (best druggability 0.50). MolNFT v1 #156801 on…
- PDB
- 6MFS
- Type
- protein
- Length
- 370 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Talin-1 fusion
- UniProt
- P26039
- Ligands
- PIO, PO4
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Talin-1 fusion | protein | 370 | 32% helix, 27% strand | P26039 |
Ligands and binding sites
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · ligand · chains A
- PO4 · Phosphate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.50 | 0.75 | 30 | empty |
| 2 | 75 | 0.33 | 0.75 | 19 | PO4 |
| 3 | 63 | 0.32 | 0.76 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26039
- Elsewhere: RCSB PDB 6MFS · PDBe 6MFS · UniProt P26039
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