MolNFT v1 · #156574 · protein

Crystal structure of the R208Q mutant of G(I) subunit alpha-1

6M8H · Guanine nucleotide-binding protein G(I) subunit alpha-1: “Crystal structure of the R208Q mutant of G(I) subunit alpha-1”. X-ray diffraction, 2 ligands (GSP, MG), 1 pocket (best druggability 0.77). MolNFT v1 #156574 on GenesisL1: 3D…

PDB: 6M8H
Type: protein
Length: 315 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(I) subunit alpha-1
UniProt: P10824
Ligands: GSP, MG
Pockets: 1 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(I) subunit alpha-1	protein	315	51% helix, 16% strand	P10824

Ligands and binding sites

GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	617	0.77	0.83	73	GSP, MG

Compared structures

6M8H · Crystal Structure of the R208Q mutant of G(i) subunit alpha-1 · the same entry in another collection · chain A against A, TM-score 1.00
P10824 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10824
Elsewhere: RCSB PDB 6M8H · PDBe 6M8H · UniProt P10824

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