MolNFT v1 · #156530 · protein
Crystal structure of enterococcus hirae L-lactate oxidase M207L in complex with lactate
6M74: “Crystal structure of enterococcus hirae L-lactate oxidase M207L in complex with lactate”. X-ray diffraction, 3 ligands (FNR, LAC, PYR), 3 pockets (best druggability 0.82). MolNFT v1 #156530 on GenesisL1: 3D structure, binding sites…
- PDB
- 6M74
- Type
- protein
- Length
- 364 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate oxidase
- EC
- 1.1.3.15
- UniProt
- I6SYK8
- Ligands
- FNR, LAC, PYR
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-lactate oxidase (EC 1.1.3.15) | protein | 364 | 45% helix, 12% strand | I6SYK8 |
Ligands and binding sites
- FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · ligand · chains A
- LAC · Lactic acid · ligand · chains A
- PYR · Pyruvic acid · ligand · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
- PGE · Triethylene glycol · additive · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.82 | 0.97 | 36 | FNR, LAC |
| 2 | 117 | 0.48 | 0.79 | 18 | empty |
| 3 | 129 | 0.43 | 0.76 | 24 | TRS |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 6M74 · Crystal structure of Enterococcus hirae L-lactate oxidase M207L in complex with D-lactate… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I6SYK8
- Elsewhere: RCSB PDB 6M74 · PDBe 6M74 · UniProt I6SYK8
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