MolNFT v1 · #156523 · protein

Crystal structure the toxin-antitoxin mnta-hpet mutant-Y104A

6M6W · Toxin-antitoxin system antidote mnt family: “Crystal structure the toxin-antitoxin mnta-hpet mutant-Y104A”. X-ray diffraction, 15 pockets (best druggability 0.80). MolNFT v1 #156523 on GenesisL1: 3D structure, binding sites and…

PDB: 6M6W
Type: protein
Length: 1,020 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Toxin-antitoxin system antidote mnt family; Toxin-antitoxin system toxin hepn family
UniProt: Q8ECH7, Q8ECH6
Pockets: 15 · best druggability 0.80

Structure

x-ray diffraction · 6 distinct chains · 69% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Toxin-antitoxin system antidote mnt family	protein	117	56% helix, 20% strand	Q8ECH7
B, C	Toxin-antitoxin system toxin hepn family	protein	132	78% helix, 0% strand	Q8ECH6
D, I	Toxin-antitoxin system toxin hepn family	protein	129	74% helix, 0% strand	Q8ECH6
F	Toxin-antitoxin system antidote mnt family	protein	123	54% helix, 18% strand	Q8ECH7
G	Toxin-antitoxin system toxin hepn family	protein	130	73% helix, 0% strand	Q8ECH6
H	Toxin-antitoxin system toxin hepn family	protein	128	78% helix, 0% strand	Q8ECH6

Pockets

15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	792	0.80	0.83	78	empty
2	682	0.78	0.83	74	empty
3	422	0.63	0.77	53	empty
4	128	0.58	0.84	27	empty
5	209	0.55	0.78	26	empty

Interfaces

15 interfaces between chains.

B–C · 872 Å² buried · 16 hydrogen bonds · protein-protein
D–I · 829 Å² buried · 11 hydrogen bonds · protein-protein
G–H · 794 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 746 Å² buried · 11 hydrogen bonds · protein-protein
F–H · 701 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6M6W · Crystal structure the toxin-antitoxin MntA-HpeT mutant-Y104A · the same entry in another collection · chain I against I, TM-score 1.00
Q8ECH6 · AlphaFold monomer V2.0 prediction for mRNA nuclease hept (Q8ECH6) · a predicted model of the same protein · chain H against A, TM-score 0.99
Q8ECH7 · AlphaFold monomer V2.0 prediction for protein adenylyltransferase mnta (Q8ECH7) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8ECH7
Every structure of UniProt Q8ECH6
Elsewhere: RCSB PDB 6M6W · PDBe 6M6W · UniProt Q8ECH7 · UniProt Q8ECH6

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.