Research workbench
Crystal structure the toxin-antitoxin mnta-hpet mutant-Y104A
Analyse Crystal structure the toxin-antitoxin mnta-hpet mutant-Y104A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M6W
- Type
- protein
- Length
- 1,020 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Toxin-antitoxin system antidote mnt family; Toxin-antitoxin system toxin hepn family
- UniProt
- Q8ECH7, Q8ECH6
- Pockets
- 15 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 69% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Toxin-antitoxin system antidote mnt family | protein | 117 | 56% helix, 20% strand | Q8ECH7 |
| B, C | Toxin-antitoxin system toxin hepn family | protein | 132 | 78% helix, 0% strand | Q8ECH6 |
| D, I | Toxin-antitoxin system toxin hepn family | protein | 129 | 74% helix, 0% strand | Q8ECH6 |
| F | Toxin-antitoxin system antidote mnt family | protein | 123 | 54% helix, 18% strand | Q8ECH7 |
| G | Toxin-antitoxin system toxin hepn family | protein | 130 | 73% helix, 0% strand | Q8ECH6 |
| H | Toxin-antitoxin system toxin hepn family | protein | 128 | 78% helix, 0% strand | Q8ECH6 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 792 | 0.80 | 0.83 | 78 | empty |
| 2 | 682 | 0.78 | 0.83 | 74 | empty |
| 3 | 422 | 0.63 | 0.77 | 53 | empty |
| 4 | 128 | 0.58 | 0.84 | 27 | empty |
| 5 | 209 | 0.55 | 0.78 | 26 | empty |
Interfaces
15 interfaces between chains.
- B–C · 872 Ų buried · 16 hydrogen bonds · protein-protein
- D–I · 829 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 794 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 746 Ų buried · 11 hydrogen bonds · protein-protein
- F–H · 701 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6M6W · Crystal structure the toxin-antitoxin MntA-HpeT mutant-Y104A · the same entry in another collection · chain I against I, TM-score 1.00
- Q8ECH6 · AlphaFold monomer V2.0 prediction for mRNA nuclease hept (Q8ECH6) · a predicted model of the same protein · chain H against A, TM-score 0.99
- Q8ECH7 · AlphaFold monomer V2.0 prediction for protein adenylyltransferase mnta (Q8ECH7) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ECH7
- Every structure of UniProt Q8ECH6
- Elsewhere: RCSB PDB 6M6W · PDBe 6M6W · UniProt Q8ECH7 · UniProt Q8ECH6
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