MolNFT v1 · #156465 · protein
Human apo ferritin frozen on tem grid with amorphous nickel titanium alloy supporting film
6M54 · Ferritin heavy chain: “Human apo ferritin frozen on tem grid with amorphous nickel titanium alloy supporting film”. Electron microscopy, 1 ligand (FE2), 20 pockets (best druggability 0.75). MolNFT v1 #156465 on GenesisL1: 3D…
- PDB
- 6M54
- Type
- protein
- Length
- 4,104 residues
- Chains
- 24
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P02794
- Ligands
- FE2
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | Ferritin heavy chain (EC 1.16.3.1) | protein | 171 | 73% helix, 1% strand | P02794 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 6 copies · chains A, D, Q, T, B, C, R, S, E, H, M, P, F, G, N, O, I, L, V, W, J, K, U, X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.75 | 0.98 | 12 | empty |
| 2 | 75 | 0.74 | 0.97 | 13 | empty |
| 3 | 74 | 0.73 | 0.97 | 13 | empty |
| 4 | 76 | 0.73 | 0.97 | 13 | empty |
| 5 | 74 | 0.73 | 0.97 | 14 | empty |
Interfaces
71 interfaces between chains.
- A–V · 1520 Ų buried · 14 hydrogen bonds · protein-protein
- H–R · 1519 Ų buried · 12 hydrogen bonds · protein-protein
- I–P · 1519 Ų buried · 13 hydrogen bonds · protein-protein
- B–W · 1518 Ų buried · 12 hydrogen bonds · protein-protein
- D–U · 1517 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6M54 · Human apo ferritin frozen on TEM grid with Amorphous nickel titanium alloy supporting film · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02794
- Elsewhere: RCSB PDB 6M54 · PDBe 6M54 · UniProt P02794
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