MolNFT v1 · #156457 · protein
Crystal structure of fkbp-frb T2098L mutant in complex with rapamycin
6M4U: “Crystal structure of fkbp-frb T2098L mutant in complex with rapamycin”. X-ray diffraction, 3 ligands (RAP, ZN, CL). MolNFT v1 #156457 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6M4U
- Type
- protein
- Length
- 406 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P62942, P42345
- Ligands
- RAP, ZN, CL
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 108 | — | P62942 |
| B | — | protein | 93 | — | P42345 |
| E | — | protein | 110 | — | P62942 |
| F | — | protein | 95 | — | P42345 |
Ligands and binding sites
- RAP · Rapamycin immunosuppressant drug · ligand · 2 copies · chains A, B, F, E
- ZN · Zinc ion · metal · 14 copies · chains A, B, F, E
- CL · Chloride ion · ion · 7 copies · chains A, E, B, F
- GOL · Glycerol · additive · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6M4U · Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin · the same entry in another collection · chain F against F, TM-score 1.00
- P62942 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1A (P62942) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P42345 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mtor (P42345) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62942
- Every structure of UniProt P42345
- Elsewhere: RCSB PDB 6M4U · PDBe 6M4U · UniProt P62942 · UniProt P42345
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