Crystal structure of human methionine aminopeptidase (HSMETAP1B) in complex with an-P2-5H-06

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 23% strand (DSSP).

Ligands and binding sites

• EYF · 1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide · ligand · chains A
• CO · Cobalt (II) ion · metal · 2 copies · chains A
• NA · Sodium ion · metal · chains A
• MG · Magnesium ion · metal · chains A
• GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6LZB · crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P53582 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 1 (P53582) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53582
• Elsewhere: RCSB PDB 6LZB · PDBe 6LZB · UniProt P53582