MolNFT v1 · #156176 · protein
Crystal structure of FGFR3 in complex with pyrimidine derivative
6LVM · Fibroblast growth factor receptor 3: “Crystal structure of FGFR3 in complex with pyrimidine derivative”. X-ray diffraction, 1 ligand (EVR), 2 pockets (best druggability 0.69). MolNFT v1 #156176 on GenesisL1: 3D structure, binding…
- PDB
- 6LVM
- Type
- protein
- Length
- 288 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 3
- EC
- 2.7.10.1
- UniProt
- P22607
- Ligands
- EVR
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 3 (EC 2.7.10.1) | protein | 288 | 39% helix, 18% strand | P22607 |
Ligands and binding sites
- EVR · 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.69 | 0.82 | 37 | EVR |
| 2 | 56 | 0.28 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 6LVM · Crystal structure of FGFR3 in complex with pyrimidine derivative · the same entry in another collection · chain A against A, TM-score 1.00
- P22607 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 3 (P22607) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22607
- Elsewhere: RCSB PDB 6LVM · PDBe 6LVM · UniProt P22607
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