MolNFT v1 · #156104 · protein

Structure of human baf base module

6LTH · Transcription activator BRG1: “Structure of human baf base module”. Electron microscopy, 1 ligand (ZN), 20 pockets (best druggability 0.83). MolNFT v1 #156104 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6LTH
Type: protein
Length: 1,845 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription activator BRG1; At-rich interactive domain-containing protein 1A…
EC: 3.6.4.-
UniProt: P51532, O14497, Q12824, Q8TAQ2, Q96GM5, Q969G3, Q92785
Ligands: ZN
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 8 distinct chains · 59% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
I	Transcription activator BRG1 (EC 3.6.4.-)	protein	120	71% helix, 0% strand	P51532
L	At-rich interactive domain-containing protein 1A	protein	466	55% helix, 2% strand	O14497
M	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	protein	259	39% helix, 22% strand	Q12824
N	SWI/SNF complex subunit SMARCC2	protein	261	74% helix, 2% strand	Q8TAQ2
O	SWI/SNF complex subunit SMARCC2	protein	325	62% helix, 3% strand	Q8TAQ2
P	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	protein	239	65% helix, 5% strand	Q96GM5
Q	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	protein	105	71% helix, 0% strand	Q969G3
R	Zinc finger protein ubi-D4	protein	70	39% helix, 17% strand	Q92785

Ligands and binding sites

ZN · Zinc ion · metal · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1109	0.83	0.84	115	empty
2	1101	0.81	0.82	115	empty
3	795	0.81	0.84	89	empty
4	584	0.76	0.83	60	empty
5	317	0.72	0.85	41	empty

Interfaces

24 interfaces between chains.

N–O · 2957 Å² buried · 17 hydrogen bonds · protein-protein
O–P · 2583 Å² buried · 17 hydrogen bonds · protein-protein
L–P · 2518 Å² buried · 34 hydrogen bonds · protein-protein
N–P · 2085 Å² buried · 5 hydrogen bonds · protein-protein
I–L · 1972 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

6LTH · Structure of human BAF Base module · the same entry in another collection · chain R against R, TM-score 1.00
O14497 · AlphaFold monomer V2.0 prediction for at-rich interactive domain- containing protein 1A… · a predicted model of the same protein · chain L against A, TM-score 0.99
Q12824 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain M against A, TM-score 0.94
Q96GM5 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain P against A, TM-score 0.86
Q969G3 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain Q against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51532
Every structure of UniProt O14497
Every structure of UniProt Q12824
Every structure of UniProt Q8TAQ2
Every structure of UniProt Q96GM5
Every structure of UniProt Q969G3
Every structure of UniProt Q92785
Elsewhere: RCSB PDB 6LTH · PDBe 6LTH · UniProt P51532 · UniProt O14497 · UniProt Q12824 · UniProt Q8TAQ2 · UniProt Q96GM5 · UniProt Q969G3 · UniProt Q92785

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