MolNFT v1 · #156038 · protein
Crystal structure of gfpuv complexed with the nanobody LAG16 at 1.67 angstron resolution
6LR7 · Green fluorescient protein UV: “Crystal structure of gfpuv complexed with the nanobody LAG16 at 1.67 angstron resolution”. X-ray diffraction, 1 ligand (CRO), 2 pockets (best druggability 0.76). MolNFT v1 #156038 on GenesisL1: 3D…
- PDB
- 6LR7
- Type
- protein
- Length
- 356 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green fluorescient protein UV; Nanobody LAG16
- Ligands
- CRO
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Green fluorescient protein UV | protein | 231 | 12% helix, 53% strand | — |
| B | Nanobody LAG16 | protein | 125 | 11% helix, 48% strand | — |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.76 | 0.97 | 29 | CRO |
| 2 | 52 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 735 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor, 1 disulfide (chromophore, disulfide).
Compared structures
- 6LR7 · Crystal structure of GFPuv complexed with the nanobody LaG16 at 1.67 Angstron resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6LR7 · PDBe 6LR7
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