MolNFT v1 · #155952 · protein
Crystal structure of the catalytic domain of human ubiquitin ligase AREL1
6LOH · Apoptosis-resistant E3 ubiquitin protein ligase 1: “Crystal structure of the catalytic domain of human ubiquitin ligase AREL1”. X-ray diffraction, 17 pockets (best druggability 0.81). MolNFT v1 #155952 on GenesisL1: 3D structure…
- PDB
- 6LOH
- Type
- protein
- Length
- 1,120 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis-resistant E3 ubiquitin protein ligase 1
- EC
- 2.3.2.26
- UniProt
- O15033
- Pockets
- 17 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) | protein | 373 | 49% helix, 13% strand | O15033 |
| B | Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) | protein | 375 | 51% helix, 13% strand | O15033 |
| C | Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) | protein | 372 | 49% helix, 11% strand | O15033 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1111 | 0.81 | 0.82 | 112 | empty |
| 2 | 472 | 0.73 | 0.82 | 42 | empty |
| 3 | 627 | 0.69 | 0.77 | 46 | empty |
| 4 | 340 | 0.61 | 0.78 | 34 | empty |
| 5 | 81 | 0.57 | 0.87 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1048 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 540 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 507 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6LOH · Crystal structure of the catalytic domain of human ubiquitin ligase AREL1 · the same entry in another collection · chain A against A, TM-score 1.00
- O15033 · AlphaFold monomer V2.0 prediction for apoptosis-resistant E3 ubiquitin protein ligase 1… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15033
- Elsewhere: RCSB PDB 6LOH · PDBe 6LOH · UniProt O15033
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