MolNFT v1 · #155937 · protein
Cryo-EM structure of immature zika virus
6LNU · Genome polyprotein: “Cryo-EM structure of immature zika virus”. Electron microscopy, 3 pockets (best druggability 0.40). MolNFT v1 #155937 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LNU
- Type
- protein
- Length
- 1,998 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48
- UniProt
- A0A024B7W1
- Pockets
- 3 · best druggability 0.40
Structure
electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Genome polyprotein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 503 | 0% helix, 0% strand | A0A024B7W1 |
| D, E, F | Genome polyprotein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 163 | 0% helix, 0% strand | A0A024B7W1 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.40 | 0.73 | 33 | empty |
| 2 | 92 | 0.36 | 0.73 | 32 | empty |
| 3 | 56 | 0.29 | 0.73 | 30 | empty |
Interfaces
4 interfaces between chains.
- B–E · 507 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 416 Ų buried · 0 hydrogen bonds · protein-protein
- C–F · 338 Ų buried · 0 hydrogen bonds · protein-protein
- A–E · 38 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6LNU · Cryo-EM structure of immature Zika virus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024B7W1
- Elsewhere: RCSB PDB 6LNU · PDBe 6LNU · UniProt A0A024B7W1
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