MolNFT v1 · #155909 · protein
Cryo-EM structure of the calhm chimeric construct (8-mer)
6LMW · Calcium homeostasis modulator 1,CALCIUM homeostasis…: “Cryo-EM structure of the calhm chimeric construct (8-mer)”. Electron microscopy, 20 pockets (best druggability 0.64). MolNFT v1 #155909 on GenesisL1: 3D structure, binding sites…
- PDB
- 6LMW
- Type
- protein
- Length
- 1,472 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium homeostasis modulator 1,CALCIUM homeostasis modulator protein 2
- UniProt
- H2MCM1, Q9HA72
- Pockets
- 20 · best druggability 0.64
Structure
electron microscopy · 1 distinct chain · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Calcium homeostasis modulator 1,CALCIUM homeostasis modulator protein 2 | protein | 184 | 68% helix, 0% strand | H2MCM1, Q9HA72 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.64 | 0.75 | 46 | empty |
| 2 | 545 | 0.63 | 0.75 | 47 | empty |
| 3 | 556 | 0.63 | 0.75 | 45 | empty |
| 4 | 532 | 0.63 | 0.75 | 46 | empty |
| 5 | 550 | 0.63 | 0.74 | 47 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1263 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 1262 Ų buried · 9 hydrogen bonds · protein-protein
- F–G · 1260 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 1260 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 1260 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 6LMW · Cryo-EM structure of the CALHM chimeric construct (8-mer) · the same entry in another collection · chain H against H, TM-score 1.00
- Q9HA72 · AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 2 (Q9HA72) · a predicted model of the same protein · chain D against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H2MCM1
- Every structure of UniProt Q9HA72
- Elsewhere: RCSB PDB 6LMW · PDBe 6LMW · UniProt H2MCM1 · UniProt Q9HA72
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