MolNFT v1 · #155861 · protein
Crystal structure of mouse DCAR2 crd domain complex
6LKR · C-type lectin domain family 4, member B1: “Crystal structure of mouse DCAR2 crd domain complex”. X-ray diffraction, 1 ligand (CA), 4 pockets (best druggability 0.60). MolNFT v1 #155861 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6LKR
- Type
- protein
- Length
- 264 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C-type lectin domain family 4, member B1
- UniProt
- Q9D8Q7
- Ligands
- CA
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | C-type lectin domain family 4, member B1 | protein | 132 | 17% helix, 32% strand | Q9D8Q7 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.60 | 0.84 | 25 | empty |
| 2 | 148 | 0.45 | 0.76 | 22 | empty |
| 3 | 64 | 0.34 | 0.77 | 17 | empty |
| 4 | 51 | 0.28 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 591 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6LKR · Crystal structure of mouse DCAR2 CRD domain complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9D8Q7
- Elsewhere: RCSB PDB 6LKR · PDBe 6LKR · UniProt Q9D8Q7
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