MolNFT v1 · #155852 · protein
Two-component system protein mediate signal transduction
6LKH · ABC transporter, solute-binding protein: “Two-component system protein mediate signal transduction”. X-ray diffraction, 1 ligand (G6P), 8 pockets (best druggability 0.72). MolNFT v1 #155852 on GenesisL1: 3D structure, binding sites…
- PDB
- 6LKH
- Type
- protein
- Length
- 928 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ABC transporter, solute-binding protein; Sensor protein kinase hpts
- EC
- 2.7.13.3
- UniProt
- X5DVD1, Q2G1E0
- Ligands
- G6P
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ABC transporter, solute-binding protein | protein | 294 | 43% helix, 21% strand | X5DVD1 |
| D, C | Sensor protein kinase hpts (EC 2.7.13.3) | protein | 170 | 35% helix, 34% strand | Q2G1E0 |
Ligands and binding sites
- G6P · 6-O-phosphono-alpha-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 346 | 0.72 | 0.84 | 35 | empty |
| 2 | 100 | 0.69 | 0.92 | 23 | G6P |
| 3 | 90 | 0.69 | 0.93 | 22 | G6P |
| 4 | 274 | 0.57 | 0.78 | 36 | empty |
| 5 | 260 | 0.56 | 0.77 | 35 | empty |
Interfaces
4 interfaces between chains.
- A–B · 593 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 351 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 338 Ų buried · 5 hydrogen bonds · protein-protein
- D–C · 300 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt X5DVD1
- Every structure of UniProt Q2G1E0
- Elsewhere: RCSB PDB 6LKH · PDBe 6LKH · UniProt X5DVD1 · UniProt Q2G1E0
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