MolNFT v1 · #15559 · protein
Biochemical and structural studies of malate synthase from mycobacterium tuberculosis
1N8I · Probable malate synthase G: “Biochemical and structural studies of malate synthase from mycobacterium tuberculosis”. X-ray diffraction, 2 ligands (GLV, MG), 8 pockets (best druggability 0.67). MolNFT v1 #15559 on GenesisL1: 3D…
- PDB
- 1N8I
- Type
- protein
- Length
- 701 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable malate synthase G
- EC
- 4.1.3.2
- UniProt
- P0A5J4
- Ligands
- GLV, MG
- Pockets
- 8 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable malate synthase G (EC 4.1.3.2) | protein | 701 | 48% helix, 18% strand | P0A5J4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.67 | 0.83 | 50 | MG, GLV |
| 2 | 183 | 0.61 | 0.83 | 29 | empty |
| 3 | 151 | 0.53 | 0.80 | 27 | empty |
| 4 | 186 | 0.52 | 0.78 | 17 | empty |
| 5 | 57 | 0.42 | 0.82 | 21 | empty |
Compared structures
- 1N8I · Biochemical and Structural Studies of Malate Synthase from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A5J4
- Elsewhere: RCSB PDB 1N8I · PDBe 1N8I · UniProt P0A5J4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.