MolNFT v1 · #155568 · protein
Structure of SIL1-bound FEM1C
6LBN · Protein fem-1 homolog C,PEPTIDE from nucleotide exchange…: “Structure of SIL1-bound FEM1C”. X-ray diffraction, 9 pockets (best druggability 0.66). MolNFT v1 #155568 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LBN
- Type
- protein
- Length
- 755 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein fem-1 homolog C,PEPTIDE from nucleotide exchange factor SIL1
- UniProt
- Q96JP0, Q9H173
- Pockets
- 9 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein fem-1 homolog C,PEPTIDE from nucleotide exchange factor SIL1 | protein | 385 | 53% helix, 3% strand | Q96JP0, Q9H173 |
| B | Protein fem-1 homolog C,PEPTIDE from nucleotide exchange factor SIL1 | protein | 370 | 52% helix, 2% strand | Q96JP0, Q9H173 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.66 | 0.93 | 21 | empty |
| 2 | 230 | 0.57 | 0.79 | 28 | empty |
| 3 | 235 | 0.56 | 0.78 | 23 | empty |
| 4 | 201 | 0.54 | 0.78 | 30 | empty |
| 5 | 160 | 0.51 | 0.78 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 939 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6LBN · Structure of SIL1-bound FEM1C · the same entry in another collection · chain A against A, TM-score 1.00
- Q96JP0 · AlphaFold monomer V2.0 prediction for protein fem-1 homolog C (Q96JP0) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9H173 · AlphaFold monomer V2.0 prediction for nucleotide exchange factor SIL1 (Q9H173) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96JP0
- Every structure of UniProt Q9H173
- Elsewhere: RCSB PDB 6LBN · PDBe 6LBN · UniProt Q96JP0 · UniProt Q9H173
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