MolNFT v1 · #155519 · protein
Cryo-EM structure of echovirus 11 complexed with its uncoating receptor fcrn at pH 7.4
6LA6 · Capsid protein VP1: “Cryo-EM structure of echovirus 11 complexed with its uncoating receptor fcrn at pH 7.4”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #155519 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6LA6
- Type
- protein
- Length
- 1,195 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein VP1; Capsid protein VP2; Capsid protein VP3; Capsid protein VP4; IgG…
- UniProt
- P55899, P61769
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 6 distinct chains · 11% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Capsid protein VP1 | protein | 285 | 9% helix, 32% strand | — |
| B | Capsid protein VP2 | protein | 251 | 10% helix, 39% strand | — |
| C | Capsid protein VP3 | protein | 238 | 9% helix, 29% strand | — |
| D | Capsid protein VP4 | protein | 59 | 12% helix, 17% strand | — |
| E | IgG receptor fcrn large subunit P51 | protein | 263 | 20% helix, 35% strand | P55899 |
| F | Beta-2-microglobulin | protein | 99 | 0% helix, 46% strand | P61769 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 705 | 0.78 | 0.83 | 79 | empty |
| 2 | 485 | 0.77 | 0.85 | 77 | empty |
| 3 | 362 | 0.61 | 0.77 | 43 | empty |
| 4 | 301 | 0.55 | 0.76 | 36 | empty |
| 5 | 178 | 0.53 | 0.79 | 28 | empty |
Interfaces
10 interfaces between chains.
- A–C · 4416 Ų buried · 57 hydrogen bonds · protein-protein
- A–B · 2070 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1516 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 1492 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 1440 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6LA6 · Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 · the same entry in another collection · chain F against F, TM-score 1.00
- P55899 · AlphaFold monomer V2.0 prediction for IgG receptor fcrn large subunit P51 (P55899) · a predicted model of the same protein · chain E against A, TM-score 0.97
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain F against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55899
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6LA6 · PDBe 6LA6 · UniProt P55899 · UniProt P61769
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