MolNFT v1 · #155401 · protein
GLUK3 receptor complex with UBP301
6L6F · Glutamate receptor ionotropic, kainate 3: “GLUK3 receptor complex with UBP301”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #155401 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L6F
- Type
- protein
- Length
- 2,860 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, kainate 3
- UniProt
- G3V9I2
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Glutamate receptor ionotropic, kainate 3 | protein | 715 | 39% helix, 17% strand | G3V9I2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.88 | 0.89 | 131 | empty |
| 2 | 1193 | 0.88 | 0.89 | 141 | empty |
| 3 | 342 | 0.86 | 0.95 | 40 | empty |
| 4 | 672 | 0.83 | 0.87 | 80 | empty |
| 5 | 247 | 0.83 | 0.94 | 40 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2927 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2712 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 1474 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1044 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 509 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6L6F · GluK3 receptor complex with UBP301 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G3V9I2
- Elsewhere: RCSB PDB 6L6F · PDBe 6L6F · UniProt G3V9I2
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