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GLUK3 receptor complex with UBP301

Analyse GLUK3 receptor complex with UBP301 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6L6F
Type: protein
Length: 2,860 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor ionotropic, kainate 3
UniProt: G3V9I2
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Glutamate receptor ionotropic, kainate 3	protein	715	39% helix, 17% strand	G3V9I2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1094	0.88	0.89	131	empty
2	1193	0.88	0.89	141	empty
3	342	0.86	0.95	40	empty
4	672	0.83	0.87	80	empty
5	247	0.83	0.94	40	empty

Interfaces

6 interfaces between chains.

C–D · 2927 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 2712 Å² buried · 20 hydrogen bonds · protein-protein
A–D · 1474 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 1044 Å² buried · 1 hydrogen bond · protein-protein
B–D · 509 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6L6F · GluK3 receptor complex with UBP301 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G3V9I2
Elsewhere: RCSB PDB 6L6F · PDBe 6L6F · UniProt G3V9I2

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