MolNFT v1 · #155271 · protein
Crystal structure of CK2A1 H115Y with hematein
6L22 · Casein kinase II subunit alpha: “Crystal structure of CK2A1 H115Y with hematein”. X-ray diffraction, 1 ligand (E3U), 3 pockets (best druggability 0.66). MolNFT v1 #155271 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L22
- Type
- protein
- Length
- 334 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II subunit alpha
- EC
- 2.7.11.1
- UniProt
- P68400
- Ligands
- E3U
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Casein kinase II subunit alpha (EC 2.7.11.1) | protein | 334 | 42% helix, 14% strand | P68400 |
Ligands and binding sites
- E3U · (6AR)-3,4,6A,10-tetrakis(oxidanyl)-6,7-dihydroindeno[2, 1-c]chromen-9-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.66 | 0.79 | 49 | E3U |
| 2 | 55 | 0.36 | 0.79 | 16 | empty |
| 3 | 50 | 0.33 | 0.78 | 13 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68400
- Elsewhere: RCSB PDB 6L22 · PDBe 6L22 · UniProt P68400
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