MolNFT v1 · #15504 · protein

Crystal structure of human RAB5A A30E mutant complex with gppnhp

1N6P · RAS-related protein rab-5A: “Crystal structure of human RAB5A A30E mutant complex with gppnhp”. X-ray diffraction, 2 ligands (GNP, MG), 1 pocket (best druggability 0.49). MolNFT v1 #15504 on GenesisL1: 3D structure, binding sites…

PDB: 1N6P
Type: protein
Length: 164 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS-related protein rab-5A
UniProt: P20339
Ligands: GNP, MG
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS-related protein rab-5A	protein	164	40% helix, 26% strand	P20339

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.49	0.80	25	MG, GNP

Compared structures

1N6P · Crystal Structure of Human Rab5a A30E mutant complex with GppNHp · the same entry in another collection · chain A against A, TM-score 1.00
P20339 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-5A (P20339) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20339
Elsewhere: RCSB PDB 1N6P · PDBe 1N6P · UniProt P20339

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