MolNFT v1 · #154772 · protein
Complex structure of iota toxin enzymatic component (ia) and binding component (ib) pore with long stem
6KLW · Iota toxin component ib: “Complex structure of iota toxin enzymatic component (ia) and binding component (ib) pore with long stem”. Electron microscopy, 1 ligand (CA), 20 pockets (best druggability 0.84). MolNFT v1 #154772 on…
- PDB
- 6KLW
- Type
- protein
- Length
- 3,238 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Iota toxin component ib; Iota toxin component ia
- UniProt
- Q46221, Q46220
- Ligands
- CA
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 23% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Iota toxin component ib | protein | 406 | 15% helix, 41% strand | Q46221 |
| H | Iota toxin component ia | protein | 396 | 31% helix, 27% strand | Q46220 |
Ligands and binding sites
- CA · Calcium ion · metal · 14 copies · chains A, B, C, D, E, F, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 554 | 0.84 | 0.90 | 91 | empty |
| 2 | 520 | 0.84 | 0.90 | 77 | empty |
| 3 | 1154 | 0.79 | 0.80 | 129 | empty |
| 4 | 283 | 0.78 | 0.90 | 56 | empty |
| 5 | 1109 | 0.77 | 0.79 | 131 | empty |
Interfaces
14 interfaces between chains.
- F–G · 3395 Ų buried · 80 hydrogen bonds · protein-protein
- E–F · 3387 Ų buried · 78 hydrogen bonds · protein-protein
- A–B · 3370 Ų buried · 76 hydrogen bonds · protein-protein
- C–D · 3349 Ų buried · 77 hydrogen bonds · protein-protein
- D–E · 3343 Ų buried · 68 hydrogen bonds · protein-protein
Compared structures
- 6KLW · Complex structure of Iota toxin enzymatic component (Ia) and binding component (Ib) pore… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q46221
- Every structure of UniProt Q46220
- Elsewhere: RCSB PDB 6KLW · PDBe 6KLW · UniProt Q46221 · UniProt Q46220
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.