MolNFT v1 · #154770 · protein
Troponin of cardiac thin filament in high-calcium state
6KLU · Troponin C, slow skeletal and cardiac muscles: “Troponin of cardiac thin filament in high-calcium state”. Electron microscopy, 1 ligand (CA), 6 pockets (best druggability 0.64). MolNFT v1 #154770 on GenesisL1: 3D structure, binding…
- PDB
- 6KLU
- Type
- protein
- Length
- 332 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles; Troponin T, cardiac muscle; Troponin I…
- UniProt
- P19123, P50752, P48787
- Ligands
- CA
- Pockets
- 6 · best druggability 0.64
Structure
electron microscopy · 3 distinct chains · 70% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac muscles | protein | 150 | 62% helix, 4% strand | P19123 |
| B | Troponin T, cardiac muscle | protein | 74 | 74% helix, 0% strand | P50752 |
| C | Troponin I, cardiac muscle | protein | 108 | 77% helix, 0% strand | P48787 |
Ligands and binding sites
- CA · Calcium ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.64 | 0.78 | 43 | empty |
| 2 | 70 | 0.50 | 0.84 | 21 | empty |
| 3 | 115 | 0.45 | 0.78 | 20 | empty |
| 4 | 69 | 0.35 | 0.76 | 13 | empty |
| 5 | 77 | 0.33 | 0.75 | 17 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2156 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 1325 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 415 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6KLU · Troponin of cardiac thin filament in high-calcium state · the same entry in another collection · chain A against A, TM-score 1.00
- P50752 · AlphaFold monomer V2.0 prediction for troponin T, cardiac muscle (P50752) · a predicted model of the same protein · chain B against A, TM-score 0.90
- P48787 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P48787) · a predicted model of the same protein · chain C against A, TM-score 0.69
- P19123 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19123
- Every structure of UniProt P50752
- Every structure of UniProt P48787
- Elsewhere: RCSB PDB 6KLU · PDBe 6KLU · UniProt P19123 · UniProt P50752 · UniProt P48787
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