MolNFT v1 · #154769 · protein
Troponin of cardiac thin filament in low-calcium state
6KLT · Troponin C, slow skeletal and cardiac muscles: “Troponin of cardiac thin filament in low-calcium state”. Electron microscopy, 1 ligand (CA), 3 pockets (best druggability 0.44). MolNFT v1 #154769 on GenesisL1: 3D structure, binding…
- PDB
- 6KLT
- Type
- protein
- Length
- 310 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles; Troponin T, cardiac muscle; Troponin I…
- UniProt
- P19123, P50752, P48787
- Ligands
- CA
- Pockets
- 3 · best druggability 0.44
Structure
electron microscopy · 3 distinct chains · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac muscles | protein | 138 | 58% helix, 7% strand | P19123 |
| B | Troponin T, cardiac muscle | protein | 71 | 83% helix, 0% strand | P50752 |
| C | Troponin I, cardiac muscle | protein | 101 | 70% helix, 0% strand | P48787 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.44 | 0.78 | 21 | empty |
| 2 | 140 | 0.40 | 0.73 | 23 | empty |
| 3 | 78 | 0.39 | 0.78 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2247 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 358 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 286 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6KLT · Troponin of cardiac thin filament in low-calcium state · the same entry in another collection · chain A against A, TM-score 1.00
- P50752 · AlphaFold monomer V2.0 prediction for troponin T, cardiac muscle (P50752) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P48787 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P48787) · a predicted model of the same protein · chain C against A, TM-score 0.73
- P19123 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19123
- Every structure of UniProt P50752
- Every structure of UniProt P48787
- Elsewhere: RCSB PDB 6KLT · PDBe 6KLT · UniProt P19123 · UniProt P50752 · UniProt P48787
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