MolNFT v1 · #154622 · protein
Solution structure of bovine insulin amyloid intermediate-1
6KH9 · Insulin a chain: “Solution structure of bovine insulin amyloid intermediate-1”. Solution nmr, 1 pocket (best druggability 0.30). MolNFT v1 #154622 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KH9
- Type
- protein
- Length
- 51 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01317
- Pockets
- 1 · best druggability 0.30
Structure
solution nmr · 2 distinct chains · 39% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin a chain | protein | 21 | 43% helix, 0% strand | P01317 |
| B | Insulin B chain | protein | 30 | 37% helix, 0% strand | P01317 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.30 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 600 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6KH9 · Solution structure of bovine insulin amyloid intermediate-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01317
- Elsewhere: RCSB PDB 6KH9 · PDBe 6KH9 · UniProt P01317
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