MolNFT v1 · #154573 · protein
Crystal structure of mavc ternary complex
6KFP: “Crystal structure of mavc ternary complex”. X-ray diffraction, 4 pockets (best druggability 0.80). MolNFT v1 #154573 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KFP
- Type
- protein
- Length
- 596 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mavc; Ubiquitin-conjugating enzyme E2 N; Ubiquitin-40S ribosomal protein S27A
- EC
- 2.3.2.23
- UniProt
- A0A2S6F4I5, P61088, J3QTR3
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mavc | protein | 374 | 49% helix, 15% strand | A0A2S6F4I5 |
| B | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) | protein | 148 | 34% helix, 16% strand | P61088 |
| D | Ubiquitin-40S ribosomal protein S27A | protein | 74 | 24% helix, 35% strand | J3QTR3 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1159 | 0.80 | 0.82 | 94 | empty |
| 2 | 459 | 0.77 | 0.85 | 60 | empty |
| 3 | 76 | 0.38 | 0.77 | 21 | empty |
| 4 | 50 | 0.33 | 0.78 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–D · 1396 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 848 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 109 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2S6F4I5
- Every structure of UniProt P61088
- Every structure of UniProt J3QTR3
- Elsewhere: RCSB PDB 6KFP · PDBe 6KFP · UniProt A0A2S6F4I5 · UniProt P61088 · UniProt J3QTR3
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