MolNFT v1 · #154564 · protein
Undocked inx-6 hemichannel in a nanodisc
6KFF · Innexin-6: “Undocked inx-6 hemichannel in a nanodisc”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #154564 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KFF
- Type
- protein
- Length
- 2,576 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Innexin-6
- UniProt
- Q9U3N4
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Innexin-6 | protein | 322 | 63% helix, 2% strand | Q9U3N4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1119 | 0.85 | 0.85 | 123 | empty |
| 2 | 889 | 0.81 | 0.83 | 79 | empty |
| 3 | 937 | 0.80 | 0.82 | 84 | empty |
| 4 | 887 | 0.80 | 0.83 | 80 | empty |
| 5 | 600 | 0.80 | 0.85 | 72 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1803 Ų buried · 14 hydrogen bonds · protein-protein
- F–G · 1778 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 1776 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 1774 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 1764 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U3N4
- Elsewhere: RCSB PDB 6KFF · PDBe 6KFF · UniProt Q9U3N4
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