Research workbench

Undocked inx-6 hemichannel in a nanodisc

Analyse Undocked inx-6 hemichannel in a nanodisc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KFF
Type: protein
Length: 2,576 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Innexin-6
UniProt: Q9U3N4
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Innexin-6	protein	322	63% helix, 2% strand	Q9U3N4

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1119	0.85	0.85	123	empty
2	889	0.81	0.83	79	empty
3	937	0.80	0.82	84	empty
4	887	0.80	0.83	80	empty
5	600	0.80	0.85	72	empty

Interfaces

8 interfaces between chains.

A–B · 1803 Å² buried · 14 hydrogen bonds · protein-protein
F–G · 1778 Å² buried · 13 hydrogen bonds · protein-protein
E–F · 1776 Å² buried · 13 hydrogen bonds · protein-protein
D–E · 1774 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 1764 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

6KFF · Undocked INX-6 hemichannel in a nanodisc · the same entry in another collection · chain H against H, TM-score 1.00
Q9U3N4 · AlphaFold monomer V2.0 prediction for innexin-6 (Q9U3N4) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U3N4
Elsewhere: RCSB PDB 6KFF · PDBe 6KFF · UniProt Q9U3N4

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