MolNFT v1 · #154534 · protein
Crystal structure of mbp-tagged REV7-ipab complex
6KEA · Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER…: “Crystal structure of mbp-tagged REV7-ipab complex”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #154534 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6KEA
- Type
- protein
- Length
- 2,321 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER, invasin IPAB,HREV3
- UniProt
- P0AEX9, Q9UI95, P18011, O60673
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 41% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER, invasin IPAB,HREV3 | protein | 581 | 41% helix, 25% strand | P0AEX9, Q9UI95, P18011, O60673 |
| B | Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER, invasin IPAB,HREV3 | protein | 582 | 40% helix, 24% strand | P0AEX9, Q9UI95, P18011, O60673 |
| C | Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER, invasin IPAB,HREV3 | protein | 574 | 43% helix, 24% strand | P0AEX9, Q9UI95, P18011, O60673 |
| D | Maltose-binding periplasmic PROTEIN,LINKER,HREV7,LINKER, invasin IPAB,HREV3 | protein | 584 | 40% helix, 24% strand | P0AEX9, Q9UI95, P18011, O60673 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 760 | 0.76 | 0.81 | 67 | empty |
| 2 | 566 | 0.70 | 0.79 | 63 | empty |
| 3 | 650 | 0.66 | 0.75 | 70 | empty |
| 4 | 379 | 0.65 | 0.79 | 47 | empty |
| 5 | 416 | 0.60 | 0.75 | 50 | empty |
Interfaces
5 interfaces between chains.
- A–B · 664 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 638 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 534 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 200 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 98 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6KEA · crystal structure of MBP-tagged REV7-IpaB complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.35
- P18011 · AlphaFold monomer V2.0 prediction for invasin ipab (P18011) · a predicted model of the same protein · chain D against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt Q9UI95
- Every structure of UniProt P18011
- Every structure of UniProt O60673
- Elsewhere: RCSB PDB 6KEA · PDBe 6KEA · UniProt P0AEX9 · UniProt Q9UI95 · UniProt P18011 · UniProt O60673
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