MolNFT v1 · #15441 · protein
Cholesterol oxidase from streptomyces @ pH 4.5 (streptomyces sp. sa- coo)
1N4U: “Cholesterol oxidase from streptomyces @ pH 4.5 (streptomyces sp. sa- coo)”. X-ray diffraction, 3 ligands (FAE, PO4, OXY), 2 pockets (best druggability 0.86). MolNFT v1 #15441 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1N4U
- Type
- protein
- Length
- 498 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cholesterol oxidase
- EC
- 1.1.3.6
- UniProt
- P12676
- Ligands
- FAE, PO4, OXY
- Pockets
- 2 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cholesterol oxidase (EC 1.1.3.6) | protein | 498 | 29% helix, 24% strand | P12676 |
Ligands and binding sites
- FAE · Flavin-N7 protonated-adenine dinucleotide · ligand · chains A
- PO4 · Phosphate ion · ion · 5 copies · chains A
- OXY · Oxygen molecule · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 902 | 0.86 | 0.88 | 115 | FAE, GOL |
| 2 | 87 | 0.33 | 0.74 | 24 | empty |
Compared structures
- 1N4U · CHOLESTEROL OXIDASE FROM STREPTOMYCES @ pH 4.5 (STREPTOMYCES SP. SA-COO) · the same entry in another collection · chain A against A, TM-score 1.00
- P12676 · AlphaFold monomer V2.0 prediction for cholesterol oxidase (P12676) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12676
- Elsewhere: RCSB PDB 1N4U · PDBe 1N4U · UniProt P12676
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