MolNFT v1 · #154167 · protein

Crystal structure of ca-unbound human annexin A5 in low salt condition

6K25: “Crystal structure of ca-unbound human annexin A5 in low salt condition”. X-ray diffraction, 4 pockets (best druggability 0.55). MolNFT v1 #154167 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6K25
Type: protein
Length: 315 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A5
UniProt: P08758
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A5	protein	315	70% helix, 0% strand	P08758

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	131	0.55	0.82	25	empty
2	181	0.54	0.79	22	empty
3	120	0.47	0.79	15	empty
4	84	0.46	0.81	23	empty

Compared structures

6K25 · Crystal structure of Ca-unbound human Annexin A5 in low salt condition · the same entry in another collection · chain A against A, TM-score 1.00
P08758 · AlphaFold monomer V2.0 prediction for annexin A5 (P08758) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08758
Elsewhere: RCSB PDB 6K25 · PDBe 6K25 · UniProt P08758

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