MolNFT v1 · #15413 · protein

Crystal structure of annexin V K27E mutant

1N41: “Crystal structure of annexin V K27E mutant”. X-ray diffraction, 2 ligands (CA, SO4), 4 pockets (best druggability 0.57). MolNFT v1 #15413 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1N41
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin V
UniProt: P14668
Ligands: CA, SO4
Pockets: 4 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin V	protein	318	71% helix, 0% strand	P14668

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.57	0.85	27	empty
2	94	0.48	0.82	21	empty
3	142	0.43	0.75	19	empty
4	58	0.33	0.77	13	empty

Compared structures

1N41 · Crystal Structure of Annexin V K27E Mutant · the same entry in another collection · chain A against A, TM-score 1.00
P14668 · AlphaFold monomer V2.0 prediction for annexin A5 (P14668) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14668
Elsewhere: RCSB PDB 1N41 · PDBe 1N41 · UniProt P14668

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