MolNFT v1 · #154007 · protein
TEL1 kinase butterfly symmetric dimer
6JXC · SERINE/THREONINE-protein kinase TEL1: “TEL1 kinase butterfly symmetric dimer”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #154007 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JXC
- Type
- protein
- Length
- 2,345 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase TEL1
- EC
- 2.7.11.1
- UniProt
- P38110
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase TEL1 (EC 2.7.11.1) | protein | 2345 | 59% helix, 0% strand | P38110 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1175 | 0.85 | 0.85 | 113 | empty |
| 2 | 941 | 0.84 | 0.86 | 103 | empty |
| 3 | 592 | 0.84 | 0.89 | 77 | empty |
| 4 | 404 | 0.78 | 0.87 | 70 | empty |
| 5 | 364 | 0.76 | 0.87 | 67 | empty |
Compared structures
- 6JXC · Tel1 kinase butterfly symmetric dimer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38110
- Elsewhere: RCSB PDB 6JXC · PDBe 6JXC · UniProt P38110
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