MolNFT v1 · #153979 · protein

Yeast NPL4 zinc finger, mpn and ctd domains

6JWH · Nuclear protein localization protein 4: “Yeast NPL4 zinc finger, mpn and ctd domains”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.56). MolNFT v1 #153979 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6JWH
Type: protein
Length: 460 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear protein localization protein 4
UniProt: P33755
Ligands: ZN
Pockets: 6 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear protein localization protein 4	protein	460	32% helix, 22% strand	P33755

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A
GOL · Glycerol · additive · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	306	0.56	0.76	34	GOL
2	193	0.48	0.75	33	GOL
3	153	0.46	0.76	22	GOL
4	113	0.37	0.74	20	GOL
5	52	0.35	0.79	16	empty

Compared structures

6JWH · Yeast Npl4 zinc finger, MPN and CTD domains · the same entry in another collection · chain A against A, TM-score 1.00
P33755 · AlphaFold monomer V2.0 prediction for nuclear protein localization protein 4 (P33755) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33755
Elsewhere: RCSB PDB 6JWH · PDBe 6JWH · UniProt P33755

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