MolNFT v1 · #15395 · protein
Coupling of folding and binding in the ptb domain of the signaling protein shc
1N3H · Shc transforming protein: “Coupling of folding and binding in the ptb domain of the signaling protein shc”. Solution nmr, 4 pockets (best druggability 0.70). MolNFT v1 #15395 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1N3H
- Type
- protein
- Length
- 207 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Shc transforming protein
- UniProt
- P29353
- Pockets
- 4 · best druggability 0.70
Structure
solution nmr · 1 distinct chain · 13% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Shc transforming protein | protein | 207 | 13% helix, 19% strand | P29353 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.70 | 0.83 | 42 | empty |
| 2 | 95 | 0.65 | 0.90 | 21 | empty |
| 3 | 92 | 0.61 | 0.88 | 18 | empty |
| 4 | 105 | 0.36 | 0.74 | 15 | empty |
Compared structures
- 1N3H · Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc · the same entry in another collection · chain A against A, TM-score 1.00
- P29353 · AlphaFold monomer V2.0 prediction for shc-transforming protein 1 (P29353) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29353
- Elsewhere: RCSB PDB 1N3H · PDBe 1N3H · UniProt P29353
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