Research workbench
Coupling of folding and binding in the ptb domain of the signaling protein shc
Analyse Coupling of folding and binding in the ptb domain of the signaling protein shc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1N3H
- Type
- protein
- Length
- 207 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Shc transforming protein
- UniProt
- P29353
- Pockets
- 4 · best druggability 0.70
Structure
solution nmr · 1 distinct chain · 13% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Shc transforming protein | protein | 207 | 13% helix, 19% strand | P29353 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.70 | 0.83 | 42 | empty |
| 2 | 95 | 0.65 | 0.90 | 21 | empty |
| 3 | 92 | 0.61 | 0.88 | 18 | empty |
| 4 | 105 | 0.36 | 0.74 | 15 | empty |
Compared structures
- 1N3H · Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc · the same entry in another collection · chain A against A, TM-score 1.00
- P29353 · AlphaFold monomer V2.0 prediction for shc-transforming protein 1 (P29353) · a predicted model of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29353
- Elsewhere: RCSB PDB 1N3H · PDBe 1N3H · UniProt P29353
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