MolNFT v1 · #153794 · protein
Structural analysis of AIMP2-DX2 and HSP70 interaction
6JPV · Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase…: “Structural analysis of AIMP2-DX2 and HSP70 interaction”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #153794 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6JPV
- Type
- protein
- Length
- 305 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional…
- UniProt
- P0DMV8, Q13155
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional protein 2 | protein | 153 | 18% helix, 39% strand | P0DMV8, Q13155 |
| B | Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional protein 2 | protein | 152 | 18% helix, 39% strand | P0DMV8, Q13155 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.60 | 0.79 | 28 | empty |
| 2 | 143 | 0.52 | 0.80 | 31 | empty |
| 3 | 158 | 0.51 | 0.79 | 20 | empty |
| 4 | 97 | 0.51 | 0.82 | 17 | empty |
| 5 | 122 | 0.44 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 702 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6JPV · Structural analysis of AIMP2-DX2 and HSP70 interaction · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.71
- Q13155 · AlphaFold monomer V2.0 prediction for aminoacyl tRNA synthase complex-interacting… · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Every structure of UniProt Q13155
- Elsewhere: RCSB PDB 6JPV · PDBe 6JPV · UniProt P0DMV8 · UniProt Q13155
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