MolNFT v1 · #153658 · protein

Crystal structure of TBC1D23 N terminal domain

6JL7 · TBC1 domain family member 23: “Crystal structure of TBC1D23 N terminal domain”. X-ray diffraction, 6 pockets (best druggability 0.67). MolNFT v1 #153658 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JL7
Type: protein
Length: 444 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TBC1 domain family member 23
UniProt: Q9NUY8
Pockets: 6 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TBC1 domain family member 23	protein	444	57% helix, 5% strand	Q9NUY8

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	419	0.67	0.79	42	empty
2	116	0.56	0.84	21	empty
3	63	0.42	0.81	17	empty
4	134	0.42	0.76	17	empty
5	65	0.32	0.75	17	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

6JL7 · crystal structure of TBC1D23 N terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9NUY8 · AlphaFold monomer V2.0 prediction for TBC1 domain family member 23 (Q9NUY8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NUY8
Elsewhere: RCSB PDB 6JL7 · PDBe 6JL7 · UniProt Q9NUY8

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